SOURCE :
        Harrison's Infectious Diseases - 2010

    AUTHORS :
        ANTHONY S. FAUCI, MD
        DENNIS L. KASPER, MD

    SUMMARY :
        Despite enormous advances in diagnosis, treatment, and prevention during the twentieth century, physicians caring for patients with infectious diseases today must cope with extraordinary new challenges, including a neverending deluge of new information, the rapid evolution of the microorganisms responsible for these diseases, and formidable time and cost constraints. In no other area of medicine is the differential diagnosis so wide, and often the narrowing of the differential to a precise infection caused by a specific organism with established antimicrobial susceptibilities is a matter of great urgency.
        To inform crucial decisions about management, today’s care providers are typically turning to a variety of sources, including colleagues, print publications, and online services. Our goal in publishing Harrison’s Infectious Diseases as a stand-alone volume is to provide practitioners with a single convenient source that quickly yields accurate, accessible, up-to-date information to meet immediate clinical needs and that presents this information in the broader context of the epidemiologic, pathophysiologic, and genetic factors that underlie it. The authors of the chapters herein are acknowledged experts in their fields whose points of view represent decades of medical practice and a comprehensive knowledge of the literature. The specific recommendations of these authorities regarding diagnostic options and therapeutic regimens—including drugs of choice, doses, durations, and alternatives—take into account not just the trends and concerns of the moment but also the longer-term factors and forces that have shaped present circumstances and will continue to influence future developments.
        Among these forces are the changing prevalence, distribution, features, and management alternatives in different regions of the world; accordingly, these topics are addressed from an international perspective.

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